Insulin

Learning objectives for this Activity:

By the end of this module, you'll be able to:
Understand the mechanism of insulin generation from proinsulin as well as insulin multimerization and storage.

Identify the mechanisms that maintain glucose homeostasis in the fed and fasted state.

Understand why diabetes mimics the unopposed extreme fasted state that results in hyperglycemia, hyperlipidemia and ketoacidosis.

Describe the mechanisms of action of sulfonylurea drugs and GLP-1 analogs in the pancreatic beta cell.

Treat diabetes by understanding the onset, peak, and duration of the available insulins.


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