Colitis-associated Cancer and Inflammation


You will be viewing four modules that discuss the relationship between inflammation and disease.

These modules are centered around the pillars of Cancer Biology, Cardiovascular disease, Metabolism and Microbial Pathogenesis.

They are meant to help you understand and make connections between a basic process such as inflammation and diseases such as colon cancer, atherosclerosis, diabetes mellitus and tuberculosis.

At the end of this module, you will be able to:

Learning objectives for this Activity:

Describe the relationship between chronic inflammation and cancer using inflammatory bowel disease as the model.

List differences between sporadic and colitis-associated cancers of the colon with respect to cancer development, treatment, and molecular pathogenesis.

Explain the presumed role of oxidative stress in the development of cancer.

Describe the origin of the free radicals which contribute to oxidative stress.

Explain how the healing process contributes to cancer development in epithelial cells and Provide an explanation of the mechanism(s) by which amino-salicylates reduce the risk of cancer development in inflammatory bowel disease.

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