Microbial Pathogenesis of CNS TB

Description:
Welcome to the learning module for “microbial pathogenesis of CNS Tuberculosis and host defense” in the Clinical Neurology clerkship. The learning goal of this module is to explore the relationship between microbial pathogenesis, host defense and CNS anatomy using a case-based format. Specifically, we will revisit fundamental concepts taught in neuro-anatomy, histology, microbiology and immunology and describe how they produce the clinical entity of central nervous system tuberculosis.

By the end of this module, you should be able to:
Learning objectives for this Activity:

Identify the trajectories of tuberculosis infection

Recognize the common clinical presentations and radiographic findings of CNS tuberculosis

Discuss the various anatomical routes by which microbial pathogens gain access to the CNS

Distinguish CSF findings of bacterial, mycobacterial, and viral meningitis

Describe the pathological role that excessive host inflammation may play in CNS infections and discuss the therapeutic implications of a genetic susceptibility marker for excessive vs. insufficient inflammation in response to mycobacterial infections.


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