Microbial Pathogenesis of CNS TB
Welcome to the learning module for “microbial pathogenesis of CNS Tuberculosis and host defense” in the Clinical Neurology clerkship. The learning goal of this module is to explore the relationship between microbial pathogenesis, host defense and CNS anatomy using a case-based format. Specifically, we will revisit fundamental concepts taught in neuro-anatomy, histology, microbiology and immunology and describe how they produce the clinical entity of central nervous system tuberculosis.
By the end of this module, you should be able to:
Learning objectives for this Activity:
Identify the trajectories of tuberculosis infection
Recognize the common clinical presentations and radiographic findings of CNS tuberculosis
Discuss the various anatomical routes by which microbial pathogens gain access to the CNS
Distinguish CSF findings of bacterial, mycobacterial, and viral meningitis
Describe the pathological role that excessive host inflammation may play in CNS infections and discuss the therapeutic implications of a genetic susceptibility marker for excessive vs. insufficient inflammation in response to mycobacterial infections.
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