Pharmacological Principle: Drug Elimination


Reviewed by Ann Danoff and Allen Clarkson.

Learners will be able to recognize the importance of drug excretion in the clinical management of glycemic control and modify medical regimens for diabetes to account for changes in renal drug elimination. After completing this exercise, a student will be able to:


Learning objectives for this Activity:

Use on-line resources to quickly estimate glomerular filtration rate and creatinine clearance

Describe the concept of drug clearance

Recognize the impact of renal dysfunction upon potential toxicities of renally cleared drugs

Recognize the causes, signs, symptoms, and treatment of hypoglycemia

Describe adjustments in diabetes medications in the setting of renal dysfunction


Use the half-life equation to quantitatively estimate changes precipitated by renal dysfunction in the time required for drug elimination

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