Pharmacological Principle: Drug metabolism via cytochrome P450 pathways


Goal: Improve knowledge of drug metabolism and its importance in drug-drug interactions.

After completing this exercise, you will be able to:


Learning objectives for this Activity:

Recognize a symptomatic drug interaction

List several pathways of drug metabolism

Use reference material to determine the route of a given drug’s metabolism

Differentiate between the effects of cytochrome P450 enzyme induction and inhibition on the pharmacologic action of drug substrate

You will also:

Review the concept of the therapeutic window

Use reference material to appropriately adjust drug dosages to account for metabolic interaction

Review mechanisms of antimicrobial drug resistance

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